Neuroimaging Correlates of Delusions in Alzheimer's Disease and Related
Dementias
 
   Lead Investigator:    Corinne Fischer
   Institution      :     
   E-Mail           :    FischerC@smh.ca
   Proposal ID      :    573


   Publications:


1  Fischer C
   Neuroimaging correlates of delusions in Alzheimer's Disease and related dementias
   41672   Grant  CIHR   CSE313912   , 

   FUNDED



2  Fischer C, Qian W, Schweizer T, Ismail Z, Smith EE, Millikin C, Munoz D
   Determining the impact of psychosis on rates of false-positive and false-negative diagnosis in Alzheimer's disease
   Journal Article  Alzheimers Dement (N Y),3:385-392,2017,PMC5651446

   PUBLISHED



3  Fischer CE, Qian W, Schweizer TA, Millikin C, Ismail Z, Smith EE, Lix LM, Shelton P, Munoz D
   Lewy Bodies, Vascular Risk Factors, and Subcortical Arteriosclerotic Leukoencephalopathy, but not Alzheimer Pathology, are Associated with Development of Psychosis in Alzheimer's Disease
   Journal Article  J Alzheimers Dis,50:283-295,2015,PMC4844451

   PUBLISHED



4  Fischer CE, Qian W, Schweizer TA, Millikin C, Ismail Z, Smith EE, Lix LM, Shelton P, Munoz DG
   Vascular risk factors and Subcortical Arteriosclerotic Leukoencephalopathy, but not Alzheimer lesion load, are associated with the development of psychosis in Alzheimer's disease
   Abstract  Can Geriatr J,18(4):246,2015,

   PUBLISHED



5  Fischer CE, Qian W, Schweizer TA, Millikin CP, Ismail Z, Smith EE, Lix LM, Shelton P, Munoz DG
   Vascular risk factors and Subcortical Arteriosclerotic Leukoencephalopathy, but not Alzheimer lesion load, are associated with the development of psychosis in Alzheimer's disease
   Abstract  Am J Geriatr Psychiatry,24(3) Supplement 1:S142,2015,

   PUBLISHED



6  Garcia-Segura EG, Kim J, Fischer CE, Schweizer TA, Munoz DG
   APOE4 is Associated with Aberrant Motor Behaviour in Women with High Load Alzheimer's Disease Pathology
   Abstract  AAIC 2018,7:P807-808,2018,

   PUBLISHED



7  Garcia-Segura EG, Kim J, Fischer CE, Schweizer TA, Munoz DG
   Concurrent Lewy Body and Cerebral Amyloid Angiopathy Mediate APOE4 Association with Aberrant Motor Behaviour in AD Load
   2019   Abstract  AAIC 2019 , 

   PRESENTED



8  Kim J, Fischer CE, Schweizer TA, Munoz DG
   Impact of Hypertension on Delusions in Patients with Severe Alzheimer's disease
   Abstract  Alzheimers Dement,12:P955,2016,

   PUBLISHED



9  Kim J, Fischer CE, Schweizer TA, Munoz DG
   Gender and pathology-specific effect of Apolipoprotein E genotype on psychosis in Alzheimer's disease
   Journal Article  Curr Alzheimer Res,14:834-840,2017,PMC5837801

   PUBLISHED



10  Kim J, Schweizer TA, Fischer CE, Munoz DG
   Psychosis In "Cognitively Asymptomatic" Elderly Subjects Is Associated with Neuritic Plaque Load, Not Neurofibrillary Tangles
   2018   Journal Article  Alzheimer Dis Assoc Disord ,PMC6107422

   PUBLISHED



11  Kim J, Schweizer TA, Fischer CE, Munoz DG
   Neuritic Plaque Load as Substrate of Psychosis in Cognitively Intact Subjects
   Abstract  AAIC 2018,7:P1386,2018,

   PUBLISHED





   Proposal Description:
   Alzheimer's disease (AD) is a brain illness that is becoming more common as the population ages. In about half of patients, false beliefs, referred to as delusions, may develop. These symptoms are often associated with negative outcomes, such as increased aggression, more rapid functional decline,  and premature placement in a long term care facility. In spite of being common, it is unclear why these symptoms arise and what part of the brain is involved. Based on preliminary data from analysis of the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, a large North American database that holds clinical and imaging data on patients with AD, we were able to conclude that reduced grey matter in the right frontal lobe of the brain may be associated with the development of delusions. However, it remains unclear as to whether these findings also occur in other types of dementia (such as Parkinson's dementia and vascular dementia), or in patients with more severe dementia, and how these findings relate to brain tissue changes at autopsy. This study proposes to examine structural brain changes in a sample of Alzheimer and related dementia patients with and without delusions matched for age, education, type of dementia, and disease severity using the National Alzheimer's Co-ordinating Centre (NACC) database. The NACC database, compared to ADNI, includes patients with other types of dementia diagnoses, a broader range of disease severity, and neuropathology. We hope the findings from this study will validate our previous findings and ultimately be used to develop effective treatments for AD patients with delusions by identifying a target in the brain for treatment.